CCSVI - Expert Report Marie Rhodes - University of Ferrara Sat 5 Dec 2009, 20:25
Marie on the state of the Zamboni research.
Very good and sober.
... translated somewhat freely ...
"Hi, my name is Marie Rhodes, I'm practicing nurse and I was the second person was treated by Dr. Michael Dake at Stanford. I have secondary progressive MS diagnosed, I am since 1991. I had agreed to this facebook page as co-administrator to help you edit the overwhelming flood of mail. I am for many years as "mrhodes40" the forum "thisisms.com" (TIMS) is active and I have brought a lot of interesting medical literature for discussion at the sides of the TIMS. So I came across to this new idea when the topic was started by Joan CCSVI in December 2008.
I want from the beginning to make something very clear:
This new idea is currently unproven. Scientific accuracy requires more than the now available data to be able to say with some certainty that this is the cause of MS. It is also possible that a combination therapy offers a immunosuppressant and vascular surgery the best chance of recovery. Currently it is not known whether CCSVI is the cause of MS and whether MS after surgery remain self-sustaining disease or whether it disappears entirely. I myself am on Copaxone. Currently, no one advises them to take your medication and no longer to be treated surgically. Of this form of treatment and their prognosis is simply not enough known.
Despite the unproven status of this model is the amount of work the present much larger and scientifically accurate, as many claim. . I have heard frequently that it is "only one study" and that is wrong
Here are the facts, you get a picture.
The research team at the University of Ferrara consists of 8 people Prof. Zamboni is the Director of Research, However, it is very important to Dr. Salvi, a neurologist in the team.
All the studies listed can be viewed on the website of the Fondazione Hilarescere (Prof. Zambonis page). All were published in medical journals and all have been seen before publication by neutral experts and reviewed.
was the first journal article from Ferrara "The great idea ...". This paper describes the model and the similarities between cytokine insufficiency caused by venous blood stasis ulcers of the feet and the damage of MS lesions. [ADÜ. To the cytokines, the interferons were] in lay terms this means that the immune cells that are found in the blood stasis ulcers (ulcers), the same as the immune cells that are found in MS lesions. And since these blood stasis ulcers are caused by blockages in veins, it is suggested that MS lesions are blood stasis ulcers of the brain tissue might. Both in blood stasis ulcers and in MS lesions, a large part of the damage caused by the immune system itself when it tries to heal the affected areas.
In MS lesions was always assumed that the immune system, the total damage caused, and that an overactive system attacks healthy tissue, and it hurt, although the immune cells have no reason to be in this tissue. Consequently, the focus has been geared to suppress the immune system, but not to eliminate the triggering event as a triggering event has been suspected, but was not proved.
It is possible that our CCSVI triggering event - or is there no problem with the immune system and once the CCSVI is healed, all disappear immunological problems. Currently, no one knows.
was the second paper "Intracranial venous blood flow dynamics of multiple sclerosis" and it was performed in 89 MS patients and 60 control subjects studied. The focus of the study was to analyze to examine all persons and to determine if could be found in MS patients venous insufficiency. There are 5 Doppler ultrasound examination designed parameters and these were VERY carefully reviewed. The Italian researchers were surprised to learn that in
!!!!!!!! all !!!!!!!!
MS patients at least two of these parameters were striking. There was not "the one" single parameter, which was conspicuous in all MS patients. It was the opposite in each patient are different combinations. When a parameter was 1 and 3 may be evident, the other 2, 4 and 5 In
!!!!!!!! no !!!!!!!
healthy person was more than one parameter and striking at the
!!!!!!!! Most !!!!!!!!
none of the healthy.
The third article was called "Doppler blood flow dynamics of the venous outflow. In this test, all described in detail and explained what was to be sought to assess the cerebral venous outflow. [ADÜ. In fact, the venous system in the mind of man so far little investigated and have been described]
The fourth paper was "the benefit of the cerebral Doppler blood flow analysis in the assessment of MS and this time the study was blinded.
the 109 MS patients and the 177 control subjects, some of which had other neurological disorders, has been assigned a number. They were then examined by ultrasound experts, who did not know their diagnosis. It would have a person with ALS [ADÜ: amyotrophic lateral sclerosis, that is the disease from which Stephen Hawking suffers], can be a vascular disease or MS, they investigated - they did not know. The investigation was conducted to provide the documents with the number of patients and then sent to a researcher for evaluation to see in which and how many parameters the patients were striking. The researcher who conducted the evaluation knew nothing about the Diagnosis and knew the patient only as a meaningless number for him, which was used to assign the findings behind again.
After they get back all the test results analyzed, the "unblinding" performed. That is, they arranged the ("blind" won) test results to individual patients and diagnoses.
!!!!!!!!
it turned out, THAT ONLY THE PEOPLE WITH 2 OR MORE DISTINCTIVE BLOOD FLOW PARAMETERS OF MULTIPLE SCLEROSIS HAD.
!!!!!!!!
None of the control subjects had more than one abnormal value, most do not, even the patients who had another disease. There was no way for researchers to dupe themselves in this Verblindungsmethode, this test was blinded carefully.
The fifth article was talking about most people when they talk about Prof. Zamboni works, just like there's just this one. The work was in the same manner as the previous blinded.
In this study examined 65 MS patients and 235 control subjects who were either cardiovascular patients, or elderly people or people with other neurological diseases. Researchers have tried to find people of which one could reasonably assume that they may have vascular problems and no MS patients.
is important that after the ultrasound part of the investigation, the MS patients with at least two abnormal blood flow parameters by means of a Venograms [ADÜ. An X-ray examination of blood flow, are used in the contrast agent] could be investigated. Some of the control subjects also needed [ADÜ. For other reasons], a venogram investigation, so that could also be studied in terms of stenosis.
led the blinded part of the investigation the same result as the previous study - only MS patients showed two abnormal parameters in Doppler ultrasound. In open-label Part of the study were X-ray venogram of MS patients and made those control patients who already require this investigation.
!!!!!!!! Only in the MS patients !!!!!!!!
were actually stenosis [closures] of the neck [that code. and found the breast] veins.
It has since more articles on related topics such as iron deposits and bypass, where blood flows. Today is the 25th November and the "Liberation Treatment" article was published - were dealt with very promising results of 65 people whose stenoses with the engagement of 2 years.
There is also a blind Doppler ultrasound study of the Jacobs Neurological Institute in Buffalo in the several hundred patients after the Zamboni protocol were investigated this month [ADÜ:. di December 2009] to be published [that code. I know, the first of January 2010, the first part of a study with a total of 1,700 people at the University of Buffalo NY to be published. In this first part of the study were 500 people "blinded" examined]. Initial comments from Dr. Guttman, a top U.S. state neurologist that support their studies Prof. Zambonis results. A small open-label study by Dr. Marian Polish Simkins found in 8 MS patients also a 100% match. [ADÜ. Had in my memory We in the forum also patients in whom Dr. Simkins found no stenosis?]
The question I posed above was whether the facts are present on this research, the often repeated "this is only one study and only one researcher "show. Or the comment of another researcher, "this study was not blinded, they may have unconsciously 'in MS patients found what they sought." Or a further comment "It is impossible that he has found a 100% Übereinstimung because nothing is strength in multiple sclerosis 100%." Appearance of these comments are correct?
All these comments and share the importance these new studies down by pretending they were less well executed, and much less conclusive than they are in my humble opinion. The amount of verified patients is in the hundreds, not only in the dozens, as with most preliminary studies. The evaluation of Doppler ultrasound examination of venous return
!!!!!!!! was blinded and controlled strictly !!!!!!!! . I think by the inclusion of older people have of people with cardiovascular disease and other neurological diseases, researchers are quite strenuous attempts to refute itself by having tried 2 abnormal Doppler - parameters in humans have found no MS. Also we know from research in general, that, one has seen hundreds of patients, the results will move even in the same regions as the number of examinees is growing.
At this stage it is my opinion that the first question raised by this new model answers for a good part is:
!!!!!!!! Do people
stenosis if they have MS. The answer is probably yes.
!!!!!!!!
Beachte: das bedeutet nicht, dass jeder Feld- Wald- und Wiesenarzt mit Ultraschallgerät diese finden wird.
!!!!!!!!
You have to know what to look for.
!!!!!!!!
The important question however is: Raises the stenosis, and help the MS, the treatment of stenosis. The answer is currently unproven and really preliminary. The results of the "Liberation Procedure" are now very promising, but their repeated by many other researchers must succeed first.
This is my opening bid, I hope it has answered some questions about CCSVI. "
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